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Through this comprehensive integration, we critically evaluated current strategies, identified emergent design paradigms, and categorized the most pressing translational challenges, offering a refined understanding essential for accelerating the clinical development of brain-targeted nano-phytochemicals

on the one hand, inhibition of Nrf2 can cause ferroptosis in tumor cells, and on the other hand, activation of Nrf2 can also set off ferroptosis in tumor cells

Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and more recently developed anti-cytokine therapies (e.g., TNF- inhibitors) could help reduce systemic and neuroinflammation (Kim and Lee, 2024)

doi: 10.3389/fmicb.2013.00263 94 BayarriMAMilaraJEstornutCCortijoJ

In total, there is strong support for targeting TRIMs in an effort to develop effective therapies for a wide-array of cancers

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