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[DOI] [PubMed] [Google Scholar] 207.Kobzik L, Reid MB, Bredt DS, Stamler JS

KEGG pathway enrichment analysis indicated that this cluster was highly enriched for the vesicle cycle pathway, which is closely associated with protein secretion, as well as several other secretion-related pathways (Fig

Specifically, under PF conditions, increased ER stress in AEC2 resulted in impaired lipid synthesis, in particular a reduction in unsaturated fatty acid synthesis mediated by stearoyl coenzyme A desaturase 1 (SCD1) Reduced SCD1 activity not only impeded resolution of endoplasmic reticulum stress, but also exacerbated cellular dysfunction, thereby triggering a fibrotic response (Romero et al., 2018a)

Jernern F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD