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This increase subsequently amplifies TCR signaling and promotes antitumor activity

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In summary, the CPZ model has been shown to mimic many aspects of human demyelinating diseases such as MS, and to be a useful experimental approach to study these diseases and test potential therapies, especially after its standardization on C57BL/6 mice (Vega-Riquer et al., 2019

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While mitochondria have diverse roles in regulating pyroptosis, there is limited evidence of their significance in neutrophils, which contain low numbers of mitochondria