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Description

FIGURE 8 TABLE 1 GPX family structural characteristics

Copper Ion (Cu)

We know now that the role of TBK1 in regulating selective autophagy is much broader than previously thought with recent studies implicating TBK1 in the direct recruitment of cargo receptors as well as the early autophagic machinery to intracellular bacteria and mitochondria, which will be described in more detail below (99)

10.1016/j.bbadis.2015.04.017 63 KisselevaT.BrennerD

Author contributions SS and JJ conceived, designed, and performed the analysis

137 CYP2E1 overexpression triggers ROS accumulation, enhancing the interaction between disheveled segment polarity protein 2 (Dvl2) and Kelch-like protein 12 and thereby inducing the ubiquitination and degradation of Dvl2 and suppressing tumor growth via Wnt/-catenin signaling