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2.2 Chronic venous insufficiency Two RDP studies on chronic venous insufficiency have shown another interesting clinical application of Pycnogenol (32, 33) that can be mechanistically explained by its beneficial effects on endothelial function and its anti-inflammatory action (65)

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Pregnant or Breastfeeding Women Supplement use during pregnancy or breastfeeding requires medical supervision Hormonal and nutritional needs differ during these periods A doctor can assess whether supplementation is appropriate or should be avoided Self-medication during pregnancy or lactation is not recommended

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Standard protocol: 2 mg weekly, typically administered as two 1mg injections spaced 3 to 4 days apart

The pancreatic tissue extracts for western blotting were prepared from four to six rats for each condition on experimental day P38