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Xanthohumol is thought to destabilize c-Myc and promotes its ubiquitination as a consequence, resulting in the suppression of Akt/ flycogen synthase kinase-3 beta (GSK3) axis and inhibition of glioblastoma cell proliferation

The standard calibration curve was plotted using gallic acid

doi: 10.1007/s12031-020-01525-8 140 LiuC.ZhangC

Moreover, since mitochondrial dysfunction and elevated ROS levels were associated with other neurodevelopmental disorders, the findings herein suggest some potential shared underlying mechanisms for these disorders as well