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The oxidative damages of biomolecules specifically of DNA due to the accumulation of hydroperoxides and other ROS ultimately lead to the loss of cell viability or cell death through various death mechanisms like apoptosis, autophagy, necrosis, ferroptosis, and mitotic catastrophe (Fig

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Med Oncol 40(9):248 Horie Y et al (2021) Molecular basis for the disruption of Keap1Nrf2 interaction via hinge & latch mechanism