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B., & Jung, J

Hence, when iron hemostasis is interrupted, excessive iron may injure proteins, lipids and DNA within mitochondria and reduce ATP production, leading to energy stress and ferroptosis (Fig

These treatments are thought to reduce systemic inflammatory mediators, such as TNF-, IL-1, and IL-6, which are known to interfere with insulin signaling pathways and contribute to insulin resistance [75, 76]

Significant comorbidity exists among these conditions, exemplified by the frequent co-occurrence of depression and ASD with epilepsy (277), the common comorbidity of depression with migraine (277), and the elevated prevalence of inflammatory bowel disease or irritable bowel syndrome among migraine patients (278)

In the context of SARS-CoV-2 infection, ABs have been linked to dysfunctional efferocytosisthe process by which apoptotic cells are cleared

While the exact mechanisms underlying this models particular sensitivity to fatal seizures remain unknown, GABAergic interneuron loss, imbalanced excitatory and inhibitory input as well as insufficient metabolic capacity to recover from seizures may be involved 25