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The used samples are from the lateral substantia nigra midbrain region, covering 9 PD patients and 5 controls, obtained in the GSE Series Matrix file format and analyzed at the log scale

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For UCD522, there were 3,877 genes differentially expressed between L522-24 and L522-72 (1974 DEGs were up-regulated and 1,903 DEGs were down-regulated), 3554 genes differentially expressed between I522-24 and I522-72 (1796 DEGs were up-regulated and 1,758 DEGs were down-regulated), whereas 439 genes differentially expressed between H522-24 and H522-72 (239 DEGs were up-regulated and 200 DEGs were down-regulated) (Figure 3)

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Protein background The insulin-like growth factors (IGFs) are a family of proteins with a similar structure to insulin

doi:10.1002/mrd.10121 79