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In various mammalian PD models, the elevated expression of NADPH oxidase 1 (Nox1) and NADPH oxidase 4 (Nox4) is a key event driving oxidative damage to dopaminergic neurons and disease progression

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Tyrosinase (EC 1.14.18.1), also termed polyphenol oxidase (PPO)a copper-containing metalloprotein is ample in bacteria, fungi, mammals, and plants 3,4 , and their active sites are exceedingly conserved between the diverse species 5,6,7,8

J., Whitledge, J

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