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In an adult focal de/remyelination mouse model of multiple sclerosis, both compounds significantly improved lesion repair in adult mice by promoting OPC differentiation while preserving the pool of OPCs, and by accelerating myelin debris clearance and shifting microglia from pro-inflammatory to pro-regenerative profiles

doi: 10.1073/pnas.0704329104 318 FarahCMichelLYMBalligandJL

A.et al (2003)

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Orita et al., 1983) and that diuretics, in general, appear to have adverse effects on renal (and muscular) glycolysis and gluconeogenesis, at least in rodents (Jones and Landon, 1967