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The first de novo synthesis of PLP occurs in bacteria, archaea, and some eukaryotes through the PDX1/PDX2-mediated condensation reaction between a pentose phosphate, a triose phosphate, and glutamine (Tambasco-Studart et al

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Development of neurodegenerative disease diagnosis and monitoring from traditional to digital biomarkers

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Fumarate is an oncometabolite and a potent inhibitor of prolyl 4-hydroxylase (P4H), which is a negative regulator of HIF-1