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Once inside the cell, the complex interacts with intracellular copper-responsive pathways which is what enables the downstream gene-modulation effects to translate from topical application into measurable dermal changes

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Regulation of the intracellular ROS level is critical for the antiproliferative effect of quercetin in the hepatocellular carcinoma cell line Hepg2

ACS Chem Biol 15:469484 Yuan J, Levitin HM, Frattini V, Bush EC, Boyett DM, Samanamud J, Ceccarelli M, Dovas A, Zanazzi G, Canoll P et al (2018) Single-cell transcriptome analysis of lineage diversity in high-grade glioma