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Because of anaphylaxis risk, intravenous B-12 administration is never recommended -intramuscular injection is the safe route

Figure 3 5 ROS in ferroptosis The concept of ferroptosis, which was first proposed in 2012 (116), is a novel model of regulated cell death (RCD) characterized by specific changes in cell morphology, such as mitochondrial atrophy and reduction or disappearance of mitochondrial cristae (117)