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184 PI3K/Akt suppression in the early stage of PAH drives endothelial apoptosis and dysfunction At the early stage of PAH, PAECs undergo apoptosis due to the inhibition of the PI3K/Akt pathway, leading to endothelial dysfunction

We therefore depleted both T and NK cells, which led to equal fungal burden and an identical phenotype in the WT and in NKG2D KO mice (Fig

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