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Feb 15, 2026 At the molecular level, semaglutide triggers something most people never think about

Samblas M, Milagro FI, Martinez A (2019) DNA methylation markers in obesity, metabolic syndrome, and weight loss

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Beta-hydroxybutyrate (BHB), a ketone body, is another interesting example BHB directly inhibits the NLRP3 inflammasome by preventing K + efflux and possibly via activation of the hydroxycarboxylic acid receptor 2 (HCA2) on immune cells (121, 122)

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