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Moreover, QUE triggered lysosomal activation by promoting the nuclear translocation of EB and activating the transcription of lysosomal genes

Without adequate NAD+, cells struggle to generate energy efficiently, repair daily damage, or maintain healthy function

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Cell Cycle 10 , 38123813 (2011)

The discovery of apoE Christchurch and the beneficial effect of the hybrid apoE2 + Christchurch variant in AD mouse models represent major breakthroughs in the field and could accelerate the development of clinical trials to assess the efficacy of AAV-mediated apoE therapy in AD [236]