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doi: 10.3389/fcimb.2026.1781905 Received 06 January 2026 Revised 07 May 2026 Accepted 18 May 2026 Published 04 June 2026 Volume 16 - 2026 Edited by Fei Pan, ETH Zrich, Switzerland Reviewed by Zeeshan Ahmad, Wayne State University, United States Ying-hao Pei, Jiangsu Provincial Hospital of Traditional Chinese Medicine, China Updates Copyright 2026 Hou, Gao, Wang, Sun, Zhang, Tian, Yang, Chen, Lian and Fang

Their protocol demonstrated the ability to restore natural melatonin cycles, reduce cortical hyperarousal, and regenerate hippocampal GABAergic neurons in patients with chronic insomnia

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The safe toxicity profilenon-mutagenic and non-hepatotoxicsuggests that SPB07393SC is not only a good drug candidate but also likely to cause fewer side effects, a key advantage in therapy

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McDonald AC, Vasey PA, Adams L, Walling J, Woodworth JR, Abrahams T, et al