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It has been noted that patients with PD and AD have higher levels of total CSF homocysteine but not free Homocysteine (Isobe et al

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Epub 2009 Mar 11 James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA: Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism

The mechanistic interpretation offered most often is straightforward: recruiting the GIP pathway alongside GLP-1 appears to add to the metabolic effect rather than substitute for it

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X-ray therapy also results in a decrease in goiter size, and frequently in myxedema, but should not be used because of the possible induction of thyroid carcinoma