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To validate whether the OsLIKE1 SNP type 2 promoter is heritable, we analyzed the OsLIKE1 promoter in progeny derived from LTH YG456 crosses, which revealed that the previously reported blast-resistant progeny exhibiting LHCB5 phosphorylation exclusively carried the OsLIKE1 type 2 promoter variant (Supplementary Data 3)

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In the three males and two females (aged 1823) who disclosed that they would be initiating the dietary supplement, we performed a total comedonal lesion and inflammatory papule count based on the acne grading system established by Allen and Smith [45]