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A subset of clinical research has also demonstrated that adding B12 (and other B-vitamins) to existing antidepressant regimens can improve response rates compared to antidepressants alone, particularly when baseline B12 was suboptimal

For reliable background on vitamin B12, see the NIH fact sheet: Vitamin B12 - Health Professional Fact Sheet

Other factors that cause cheilosis are sunny, dry, or windy weather

Post-surgical recovery Accelerating healing after orthopedic surgery, soft tissue repairs, or procedures where tissue recovery is the limiting factor

doi: 10.1136/bmj.l5047

However, this is ingredient-level research