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For example, in mice fed a 4% fat diet, short-term (4 weeks) or long-term (74 weeks) treatment with LA (20 mg/kg body weight) produced no improvement in systemic hypertriglyceridemia (HTG) and hepatic fat contents, and even significantly increased cholesterol content in rat livers despite enhanced mRNA expression of lipid oxidationrelated genes (fibroblast growth factor-21 [Fgf21], peroxisome proliferatorsactivated receptor alpha[ppar], acyl coenzyme A oxidase [acox1], carnitine palmitoyl transferase 1a and 2 [cpt1a and cpt2], recombinant retinoid X receptor a [rxra]), and ATP-binding cassette transporter A1 [abca1])

doi: 10.1016/j.chemosphere.2020.129004 42 KurebayashiHNagatsukaS-INemotoHNoguchiHOhnoY

[DOI] [PMC free article] [PubMed] [Google Scholar] 97.Hishiyama N., Kayanuma H., Matsui T., Yano H., Suganuma T., Funaba M., Fujise H

systemic oral or injectable dosing lacks large randomized controlled trials, so clinical benefit remains provisional

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