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Suanzaoren Decoction also exhibits multi-pathway and multi-targeted antidepressant effects, including anti-inflammatory actions and gut flora regulation (Table 3)

RSL3, a ferroptosis inducer, directly acts on GPX4 and inhibits its activity, thus reducing the antioxidant capacity of cells and accumulating ROS, leading to ferroptosis 12

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VipD of legionella pneumophila targets activated rab5 and rab22 to interfere with endosomal trafficking in macrophages

TB-500, the synthetic fragment of Thymosin Beta-4, has been studied for its role in actin regulation, cellular migration, and fibroblast/keratinocyte movement to injury sites