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Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure

As a result, HIF1 becomes stable in hypoxic conditions and stimulates the production of VEGF and VEGFR [9,10]

Sci Rep (2020) 10:6343

Caveolin-1, an essential structural protein in caveolae, has been shown to positively modulate the activity of extracellular SOD3 by promoting the stabilization of ATP7A protein expression

The evidence highlights the potential of redox profiling as an indicator of metabolic pathology and as a measure of treatment response

N.Torres-MendietaR.et al (2020)