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Pulsatile GH secretion means GH is released in discrete bursts rather than a steady continuous stream

reported a prodrug activation strategy that relies on the cleavage of CC bonds, successfully demonstrating the design of -lapachone ( -lap) prodrugs

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Agarwal R, MacMillan-Crow LA, Rafferty TM, Saba H, Roberts DW, Fifer EK, James LP, and Hinson JA

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doi: 10.1126/scitranslmed.aba2927 48 SwartALLaventieB-JStterlinRJunneTLauerLManfrediPet al