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While some studies suggest a possible correlation between GLP-1 RAs and intestinal obstruction, others report no significant association, with discrepancies likely due to variations in study demographics, methodologies, and GLP-1 RA formulations

Concurrently, clinicians have observed increased conception rates among individuals using GLP-1 RAs, prompting investigation into whether these effects stem from improved metabolic health or direct pharmacologic influences on reproductive physiology

7 Principal component and pathway enrichment analysis

Effects appear within days of starting treatment and accumulate with continued use

Rivera LB, Bergers G

2.1 Literature search A systematic search of the PubMed, EMBASE, Cochrane Library, Web of Science, and CNKI databases for relevant observational studies published until 15 March, 2022, was undertaken independently by two reviewers (Zhao and Li)