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These included: Expressive communication Personal and domestic daily living skills Interpersonal skills Play-leisure skills Coping social skills Other clinical improvements observed with B12 included improvements in: Sleep Gastrointestinal symptoms Hyperactivity Tantrums Nonverbal intellectual quotient Vision Eye contact Echolalia Stereotypy Anemia Nocturnal enuresis (bed wetting) Adverse events with B12 identified by meta-analysis included: Hyperactivity (11.9%) Irritability (3.4%) Trouble sleeping (7.6%) Aggression (1.8%) Worsening behaviors (7.7%) But adverse effects were generally few, mild, not serious, and not significantly different compared to placebo

Alcohol abuse can lead to vitamin B12 deficiency due to the following reasons: Alcohol consumption can reduce B-12 absorption as chronic alcohol consumption can lead to gastritis (inflammation of the stomach lining) and impair the production of intrinsic factor, which is a protein necessary for the absorption of vitamin B12

Further reading [edit] Wintrobe's Clinical Hematology Thirteenth Edition

VITAMIN C INDICATIONS FOR TREATMENT The earliest symptoms of VITAMIN C deficiency include: Rough or bumpy skin, Corkscrew shaped body hair, redness around hair follicles, Damaged or dry skin, Bruising easily, Slow healing of wounds, Painful or swollen joints, Bleeding gums & tooth loss, Poor immunity, Fatigue or poor mood, Oxidative stress and inflammation

Research into use of injectable cabotegravir and rilpivirine by children and pregnant people is currently ongoing