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CONCLUSION: DEX inhibited GSIS and preproinsulin mRNA synthesis in INS-1 cells

HT plays a key role as an anti-inflammatory agent by modulating these processes, helping to reduce excessive inflammation and support the resolution phase, which is crucial for preventing chronic inflammatory conditions [52,53]

Melatonin is an amine hormone derived from tryptophan that is primarily synthesized by the pineal gland in mammals and humans [198]

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