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It also suppressed cytokines like lipopolysaccharide, TNF-, interleukins (1 & 6), and cyclooxygenase 2, while mitigating oxidative stress and decreasing vascular endothelial growth factor levels

doi: 10.1152/ajpgi.00305.2004 11 KaplanG

These molecules were subjected to preparation in LigPrep (15) generating their ionization states at pH 7.0 (2.0) using Epik ionizer, and three lowest energy conformers were retained for each compound