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332 Of particular importance is that MLCK activation, claudin-2 overexpression, and occludin internalization have been found in intestinal tissues from both forms of IBD, namely, Crohns disease and ulcerative colitis

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First, it has been shown that in DA-resistant tumors the reduction of DRD2, previously associated with resistance, is accompanied by a low level of FLNA ( In vitro experiments starting from this experimental observation demonstrated that alterations of FLNA levels in primary cultured prolactinoma cells by gene silencing or overexpression resulted in corresponding modifications of DRD2 levels, demonstrating that these two events are causally related

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