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70 Moreover, in tissues of PDA patients, lactylation of TFEB at lysine 91 has been identified, which prevents its ubiquitination and proteasome degradation by hindering its interaction with the E3 ubiquitin ligase WWP2, enhancing TFEB activity and autophagy flux, which promotes pancreatic cancer progression

2 mM dl-propargylglycine (PPG, SigmaAldrich), 0.2 mM l-homocysteine (Hcy, SigmaAldrich), or 0.5 mM l-methionine (Met, Research Products International, Inc) was added as indicated

Neutralizing antibodies and cross-protective immune responses are studied after immunization with the entire libraries, pools and/or individual antigen variants

Ansari A, Patel N, Sanderson J, ODonohue J, Duley J, Florin T