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MED13, Mediator Complex Subunit 13

Unhealthy environments have been linked to a 25% increase in the risk of ischemic heart disease, with air pollution significantly contributing to disease prevalence, hospitalizations, disabilities, mortality, and healthcare costs (183)

Nevertheless, endogenously synthesized ALA cannot be replaced by exogenous ALA in certain physiological activities, such as mitochondrial coenzyme action

Carcinogenic Environmental Factors and Toxins Several environmental factors are associated with lung cancer development, including exposure to asbestos, diesel engine exhaust, air pollution, pesticides, and heavy metals such as cadmium and nickel (Vermeulen 2014

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However, current studies lack detailed investigation or demonstration of these mechanisms, which may reduce the depth of scientific analysis