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Normal and reactive NG2+ glial cells are distinct from resting and activated microglia

They promote the expression of catabolic enzymes (e.g., MMP-1, -2, -3, -13, and ADAMTS-4/5) and inhibit anabolic proteins like aggrecan and collagen II by activating signaling pathways such as NF-B, MAPK, and Toll-like receptors (TLR), ultimately leading to ECM degradation and tissue destruction (Yang et al., 2025

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In fact, third-party testing of the 550H showed that our 2 stage filtration system actually provided 99.99% @ 0.3m filtration, exceeding the standard

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