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In addition, combining treatments may provide a better safety profile given that lower doses of each drug when used together may achieve better weight loss than higher doses of a single agent (see Figure 1 below)

While the exact location of the neurological injury has yet to be identified since MRI (0.5 T) assessments conducted in 1993 on 2 konzo-affected individuals reported no pathological findings, the phenotypic presentation of various severities (Stages 13) of hyperreflexia and non-spastic paraparesis suggests damage of motor neurons and corresponding brain regions

Jadach B, Mielcarek Z, Osmalek T

These ICB pre-treatment CD8+ T cells in the tumors exhibit reduced effector function and lack of proliferation after ICB treatment, indicating that the cells are exhausted (201)

Studies reveal saffron improves antidepressant-caused sexual dysfunction [48]

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