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Other ALDH2 approaches: Many investigational drugs showed promise in pre-clinical studies, including selective and reversible ALDH2 inhibitors (e.g., ANS-6637) and genetic targeting of liver ALDH2 messenger RNA to locally reduce hepatic ALDH2 expression (305, 306)

As the barrier breaks down during exertion, gut bacteria and LPS translocate into the blood and persist there much longer than in healthy individuals

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It activates genomic pathways that produce neuroprotective proteins, shielding neurons from oxidative stress, inflammation, and other neurotoxic factors, thereby preserving brain health