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Monitor for any unusual reactions in the first 24 to 48 hours after starting a new peptide

Butt AM, Jones HC, Abbott NJ

This means that natural bodybuilders and sportspeople might use it without risk of bans

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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date