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Allopurinol is the first-line urate-lowering therapy and should be started at a low dose, with gradual dose escalation

The concept of Ferroptosis Ferroptosis is a novel programmed cell death, distinct from apoptosis, necrosis, pyrodeath and autophagy, that consists of iron accumulation and lipid peroxidation [12, 31, 32]

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In addition, curcumin mitigates oxidative and nitrosative stress, insulin resistance, and imbalances in the endocannabinoid system, making it a promising candidate for managing MDD (556)