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This reduces TNF- production, decreases IL-6 secretion, and lowers overall inflammatory cytokine expression

GA decreases the activity of catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD), leading to reduced scavenging ability for ROS, consequently resulting in peroxidative damage of membranes followed by release of hydrolytic enzymes (Jones and Smirnoff, 2005

Chavarria C, Rodriguez-Bottero S, Quijano C, Cassina P, Souza JM (2018) Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

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Once the reaction rate has met the minimum requirement, efforts should be put on improving the non-covalent binding contribution