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3.6 PheWas To thoroughly assess whether the identified potential drug target gene TOR1B might exert beneficial or detrimental effects on other traits, and to explore potential pleiotropy not captured by the MR-Egger intercept test, we utilized 17,361 binary phenotypes and 1,419 quantitative phenotypes from the AstraZeneca PheWAS portal

George Barth Geller Distinguished Professor of Medicine Professor of Medicine Chair, Department of Medicine Member of the Duke Cancer Institute Member of Duke Molecular Physiology Institute Chair, Department of Medicine Member of the Duke Cancer Institute Member of Duke Molecular Physiology Institute

They also found an increase in circulating antioxidants and levels of superoxide dismutase and glutathione peroxidase

Without an approved New Drug Application, no official prescribing information, black-box warnings, or overdose management protocols exist

[2] Lu, S.C