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This mechanistic insight is strongly supported by in vivo evidence showing that anti-OPN antibodies, which mimic the effect of blocking thrombin-cleaved OPN, replicate a tumor suppression phenotype in knock-in mice engineered with a thrombin cleavage-resistant form of the protein [271]

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[DOI] [PubMed] [Google Scholar] Cheng CM, Tseng V, Wang J, Wang D, Matyakhina L, Bondy CA