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In contrast, the full (liposome-encapsulated) plasma level of ribavirin in EYPC-based liposomes (again after a single intravenous injection of 50 mg/kg in rats) was found to peak at only 1 millimolar and to rapidly decline (with a half-life of about 3 hours), with no observed difference between the 0 and 2% GSH on the outer surface of the liposomes

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Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse

doi: 10.1212/wnl.0000000000010404 22 ChangB.XiongC.NiC.ChenP.JiangM.MeiJ.et al