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Drugs and biomolecules can penetrate the skin to the viable tissue by three main routes: i) the intercellular (between the corneocytes, through the lipid matrix)

While still highly significant versus baseline, the high-dose group actually produced fewer new hairs than the low-dose group consistent with the biphasic dose-response seen in the 2007 Pyo laboratory study where higher copper peptide concentrations inhibited rather than stimulated growth

Bibcode:2021GeoRL..4891374Y

Epub 2016 Jun 4 PMID: 27259496

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However, as with any medication, adverse effects can occur, and patients should be informed of potential reactions before commencing treatment