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For example, in the cytosol of hepatocytes the steady-state ratio of NADP+/NADPH is approximately 0.1, which favors the use of NADPH in reductive biosynthetic reactions

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Thus, ferroptosis can be defined as a non-apoptotic mode of regulated cell death, driven by iron accumulation and membrane lipid peroxidation when GPX4 activity is inhibited (Fig

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Targeting The Mitochondrial ClpP As a Novel Therapeutic Strategy For Acute Myeloid Leukemia