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doi: 10.3389/fphys.2022.837001 [DOI] [PMC free article] [PubMed] [Google Scholar] 352

The subsequent decrease in GSH:GSSG ratio has consequences for MGO detoxification and the redox status [65], which may ultimately alter BBB permeability

Overall, this exemplifies the dominance of redox state as a factor controlling cellular processes in L

Lipid peroxidation is a process in which ROS oxidizes biofilm after oxidative stress is enhanced, and it is a key factor driving cell death ( The accumulation of polyunsaturated fatty acids (PUFA) is considered as a sign of ferroptosis ( At the same time, the decomposition products of lipid peroxide, including 4- hydroxynonenal (HNE) and malondialdehyde (MDA), will also damage the cell process, because they form adducts with protein and DNA, thus affecting the normal function of cells ( 1.1.3 Amino acid metabolism The occurrence of ferroptosis is closely related to the depletion of intracellular GSH and the failure of antioxidant enzyme GPX4