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This reduction is tied to: Changes in cellular energy production The aging process at a cellular level Because of this, replenishing NAD+ becomes more relevant later in life

In a solid tumor model established by the subcutaneous injection of Hepa1-6 cells into B6 mice, the administration of a lactate dehydrogenase inhibitor (LDHi) significantly reduced the lactate concentration and FOXP3 expression, thereby suppressing the immunoregulatory function of Tregs in the TME

Qiu et al., 2022)