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When the upregulating MMP-9 cannot be offset by TIMP-1 abundantly, the degradation of elastin and other extracellular matrix components occurs in the alveolar walls and finally leading to emphysema (Pardo and Selman, 1999

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C., Huber R., Maskos K., Proteins , 2007 , 15 , 738

Levels between 200300 pg/mL are borderline and warrant clinical assessment