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Acta 1819 , 11421153 (2012)

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This highlights a central principle for realistic risk assessment: the toxicity of an aged, environmentally transformed ENM is often mechanistically distinct from, and usually less acute than, its pristine counterpart

GPX4 can serve as an essential bridge between the Hippo pathway and ferroptosis, and these two pathways have opposing regulatory effects on epithelial-to-mesenchymal transition (EMT)

2.1.1 Immunosuppressive drugs Since its first use in the late 80s, cyclosporine A (CsA) has revolutionized the world of transplantation by enabling patients to reduce the possibility of rejection

Noteworthy, in the same model, HIF-3 expression was decreased, probably as consequence of its hypermethylation, which negatively regulates the hypoxia signaling pathway [284, 285]