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Antioxidant and anti-inflammatory effects of IGF-I have been documented to reduce atherosclerotic burden, mainly both via cytokine response modulation (attenuating IL-6 and TNF- pro-inflammatory responses)[299] and/or eNOS activity regulation[295]

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In parallel, to determine the effect of inulin supplementation on HFCS-elicited pathologies, we used an open-source diet, a control diet used in many nutritional studies 36,37,38 , and formulated an inulin-enriched diet by replacing a small portion of corn starch (10% w/w) with inulin, as in previous studies 39,40,41 (Supplementary Table 1)

Reactive derivatives of oxygen, termed reactive oxygen species (ROS), are toxic for non-target molecules 2 , causing oxidative damage to nucleic acids, proteins and lipids 3 , reviewed by 4,5

Vitamin B12 is found primarily in animal products, making it essential for individuals, especially those following a vegetarian or vegan diet, to be mindful of their B12 intake

Glutathione injections are generally safe, but some individuals may experience mild side effects such as pain, redness, or swelling at the injection site, as well as occasional nausea or headaches