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That figure came from an assay-specific in-vitro spine-density assay (picomolar Dihexa versus nanomolar BDNF) and does not mean Dihexa is millions of times more effective in a living brain

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The sst 2a is the receptor most abundantly expressed at this site compared to other subtypes and microinjection of somatostatin into the RVLM induces a sympatho-inhibitory response mimicked by the sst 2 agonist, lanreotide and prevented by an sst 2 antagonist, BIM-23627 in rats (Burke et al., Behavioral responsefocus on food intake Brain CRF receptors are involved in the stress-related reduction of food intake in rodents (Krahn et al., 1986

TNF: tumor necrosis factor.

doi: 10.3389/fphar.2023.1230608 Received 29 May 2023 Accepted 14 November 2023 Published 03 January 2024 Volume 14 - 2023 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Wen-Chi Wei, National Research Institute of Chinese Medicine, Taiwan Md