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In addition, subclinical intestinal inflammation has been observed in treatment nave patients with early RA as well as before the onset and during the course of arthritis in animal models, and there is evidence about an impact of inflammatory cytokines (such as tumor necrosis factor (TNF) and interferon gamma (IFN)) on the integrity of TJs by reducing the levels of occludins and ZO-1 [2, 5]

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This approach minimizes side effects and allows the body to adjust

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